ABSTRACT
Introduction: Type 2 diabetes mellitus is progressive loss ofglycemic control over a period of time. So the purpose of thepresent study was to evaluate the effectiveness and safety ofthe Sitagliptin as an ‘add-on’ to the ongoing drug therapy inpatients with Type 2 Diabetes Mellitus (T2DM).Material and Methods: It was a randomized, retrospectivepopulation based cohort study done in 259 patients for 36weeks from July’12 – March’13. Patients were randomlydivided into 2 groups. In 1st group, sitagliptin was added andno ongoing drug was withdrawn while in 2nd group sitagliptinwas added and dose of ongoing therapy was reduced to half.Results: The primary efficacy endpoint was reduction inglycated haemoglobin (HbA1C), fasting blood sugar, and 2hour post prandial blood sugar evaluated after 4, 8, 12, 18 and36 weeks. A better glycemic control was observed in 1st groupthan 2nd. Sitagliptin was well tolerated without side effects.Conclusion: Addition of Sitagliptin 100mg once daily as‘add-on’ drug therapy was well tolerated with significantglycemic control in T2DM after 36 weeks.
ABSTRACT
Introduction: Thrombocytopenia is common haematologicalfinding with different specific etiologies. The aim ofpresent study was to find clinicopathological correlation ofthrombocytopenia in adults by causes, severity and clinicalpresentation.Material and Methods: This was a cross sectional studydone for a period of 6 months. After clinical profile laboratorydata and complications of patients with a platelet count of lessthan 1,50,000 were analyzed and tabulated.Results: The total sample size was 135 with 95(70.37%) malesand 40 (29.63%) females. Out of 135 patients, 32(23.70%)were diagnosed dengue. Malaria was found in 20% patients.Most cases were presented with fever(56%) followed bybodyache (40.74%), joint pain(33.33%), bleeding (17.03%)and hepatosplenomegaly(15.55%).Conclusion: Infectious diseases were the most common causeof thrombocytopenia out of which dengue was commonestfollowed by malaria and typhoid. Early recognition anddiagnosis of cause of thrombocytopenia can avoid bleedingmanifestations and serious complications.